@article{Ayesha_2018, title={Antidepressant drugs as novel spectrophotometric reagents for the determination of nano amounts of bromate in water and bread samples}, volume={3}, url={http://dx.doi.org/10.22161/ijeab/3.3.56}, DOI={10.22161/ijeab/3.3.56}, abstractNote={<jats:p>Bromate has been determined by visible spectrophotometric method in nano level by using a class of antidepressant drugs namely imipramine hydrochloride (IPH), desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH) and trimipramine hydrochloride (TPM) in presence 3-Methyl-2-benzothiazolinone hydrazone hydrochloride hydrate (MBTH) as electrophilic coupling reagent. The method involves the reduction of bromate by MBTH which then couples with the antidepressant drugs. The reaction was carried out at room temperature (27 0C) in acidic medium. The reaction produced a blue colour which gave maximum absorbance at 630 nm for MBTH-IPH/DPH/CPH/TPM method. The method obeys Beer’s law in the range of 200-1400, 300-1200,100-1200, 450-1500 ng mL-1 for IPH, DPH, CPH and TPM, respectively. The intensity of the blue colour developed was stable for 24 hours The molar absorptivity and Sandell’s sensitivity gave different values with different reagents and the method was found to be very sensitive and reproducible. To determine the selectivity of the proposed method the salts of 11 cations and 8 anions were added to a recommended concentration of bromate solution and the results obtained were very satisfactory. The method was successfully applied for the determination of bromate in water samples collected from different sources and wheat/bread samples obtained from commercial factories.

</jats:p>}, number={3}, journal={International Journal of Environment, Agriculture and Biotechnology}, publisher={AI Publications}, author={Ayesha, Syeda}, year={2018}, pages={1154–1161} }